Comparative transcriptomics across 14 Drosophila species reveals signatures of longevityстатья
Статья опубликована в высокорейтинговом журнале
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Дата последнего поиска статьи во внешних источниках: 26 декабря 2018 г.
Аннотация:Lifespan varies dramatically among species, but the biological basis is not well
understood. Previous studies in model organisms revealed the importance of nutrient
sensing, mTOR, NAD/sirtuins, and insulin/IGF1 signaling in lifespan control. By
studying life-history traits and transcriptomes of 14 Drosophila species differing
more than sixfold in lifespan, we explored expression divergence and identified
genes and processes that correlate with longevity. These longevity signatures suggested
that longer-lived flies upregulate fatty acid metabolism, downregulate neuronal
system development and activin signaling, and alter dynamics of RNA splicing.
Interestingly, these gene expression patterns resembled those of flies under dietary
restriction and several other lifespan-extending interventions, although on the individual
gene level, there was no significant overlap with genes previously reported to
have lifespan-extension effects. We experimentally tested the lifespan regulation
potential of several candidate genes and found no consistent effects, suggesting
that individual genes generally do not explain the observed longevity patterns.
Instead, it appears that lifespan regulation across species is modulated by complex
relationships at the system level represented by global gene expression.