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The roles of thiol oxidoreductases in yeast replicative agingстатья
Статья опубликована в высокорейтинговом журнале
Информация о цитировании статьи получена из
Scopus,
Web of Science
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 26 декабря 2018 г.
- Авторы: Elise Hacioglu, Isil Esmer, Fomenko Dmitri E., Gladyshev Vadim N., Ahmet Koc
- Журнал: Mechanisms of Ageing and Development
- Том: 131
- Номер: 11-12
- Год издания: 2010
- Издательство: Elsevier BV
- Местоположение издательства: Netherlands
- Первая страница: 692
- Последняя страница: 699
- Аннотация: Thiol-based redox reactions are involved in the regulation of a variety of biological functions, such as protection against oxidative stress, signal transduction and protein folding. Some proteins involved in redox regulation have been shown to modulate life span in organisms from yeast to mammals. To assess the role of thiol oxidoreductases in aging on a genome-wide scale, we analyzed the replicative life span of yeast cells lacking known and candidate thiol oxidoreductases. The data suggest the role of several pathways in controlling yeast replicative life span, including thioredoxin reduction, protein folding and degradation, peroxide reduction, PIP3 signaling, and ATP synthesis.
- Добавил в систему: Гладышев Вадим Николаевич