Cytotoxicity of nonionic amphiphilic copolymersстатья
Информация о цитировании статьи получена из
Web of Science ,
Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 18 июля 2013 г.
Авторы:
Budkina O.A. ,
Demina T.V. ,
Dorodnykh T.Y. ,
Melik-Nubarov N.S. ,
Grozdova I.D.
Журнал:
Polymer Science, Series A
Том:
54
Номер:
9
Год издания:
2012
Издательство:
Pleiades Publishing, Ltd
Местоположение издательства:
Road Town, United Kingdom
Первая страница:
707
Последняя страница:
717
DOI:
10.1134/S0965545X12080020
Аннотация:
The purpose of this study is to ascertain the relationship between the structure of an amphiphilic nonionic polymer and its toxicity for cells (cytotoxicity) growing in a culture. To this end, 16 polymers of different architectures and chemical structures are tested, namely, linear triblock copolymers of poly(ethylene oxide)-block-poly(propylene oxide)-block- poly(ethylene oxide) (Pluronics); diblock copolymers of propylene oxide, ethylene oxide, and hyperbranched polyglycerol; alternating and diblock copolymers of ethylene oxide and dimethylsiloxane; and two surfactants containing linear (Brij-35) or branched (Triton X-100) aliphatic chains. Polymer-cell interaction is assayed in a culture medium in the absence of serum. Effective concentrations of the polymers causing 50% cell death, EC50, vary within three orders of magnitude. Toxic concentrations of the alternating copolymer, Triton X-100, and Brij-35 are lower than their CMC values. In contrast, all block copolymers, regardless of their chemical structures, become toxic at concentrations above the CMC; that is, they acquire cytotoxicity only in the micellar form. The EC 50 values of the copolymers depend on their hydrophilic-liphophilic balance (HLB) through the following empirical formula: EC 50 × 10 6 = 8.71 × HLB 2.1. This relationship makes it possible to predict the cytotoxic concentration region of a block copolymer of a known structure. © Pleiades Publishing, Ltd., 2012.
Добавил в систему:
Мелик-Нубаров Николай Сергеевич