Iron metabolic pathways in the processes of sponge plasticity

Finoshin, A.D.; Adameyko, K.I.; Mikhailov, K.V.; Kravchuk, O.I.; Georgiev, A.A.; Gornostaev, N.G.; Kosevich, I.A.; Mikhailov, V.S.; Gazizova, G.R.; Shagimardanova, E.I.; Gusev, O.A.; Lyupina, Y.V.

Авторы: Finoshin Alexander D., Adameyko Kim I., Mikhailov Kirill V., Kravchuk Oksana I., Georgiev Anton A., Gornostaev Nicolay G., Kosevich Igor A., Mikhailov Victor S., Gazizova Guzel R., Shagimardanova Elena I., Gusev Oleg A., Lyupina Yulia V.
Журнал: PLoS ONE
Том: 15
Номер: 2
Год издания: 2020
Издательство: Public Library of Science
Местоположение издательства: United States
Первая страница: e0228722
DOI: 10.1371/journal.pone.0228722
Аннотация: The ability to regulate oxygen consumption evolved in ancestral animals and is intrinsically linked to iron metabolism. The iron pathways have been intensively studied in mammals, whereas data on distant invertebrates are limited. Sea sponges represent the oldest animal phylum and have unique structural plasticity and capacity to reaggregate after complete dissociation. We studied iron metabolic factors and their expression during reaggregation in the White Sea cold-water sponges Halichondria panicea and Halisarca dujardini. De novo transcriptomes were assembled using RNA-Seq data, and evolutionary trends were analyzed with bioinformatic tools. Differential expression during reaggregation was studied for H. dujardini. Enzymes of the heme biosynthesis pathway and transport globins, neuroglobin (NGB) and androglobin (ADGB), were identified in sponges. The globins mutate at higher evolutionary rates than the heme synthesis enzymes. Highly conserved iron-regulatory protein 1 (IRP1) presumably interacts with the iron-responsive elements (IREs) found in mRNAs of ferritin (FTH1) and a putative transferrin receptor NAALAD2. The reaggregation process is accompanied by increased expression of IRP1, the antiapoptotic factor BCL2, the inflammation factor NFκB (p65), FTH1 and NGB, as well as by an increase in mitochondrial density. Our data indicate a complex mechanism of iron regulation in sponge structural plasticity and help to better understand general mechanisms of morphogenetic processes in multicellular species.
Добавил в систему: Михайлов Кирилл Викторович

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Iron metabolic pathways in the processes of sponge plasticityстатья

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