Antiproliferative and antibacterial activity of extracts of Ganoderma strains grown in vitro

Serrano-Márquez, L.; Trigos, Á.; Couttolenc, A.; Padrón, J.M.; Shnyreva, A.V.; Mendoza, G.

Авторы: Serrano-Márquez Leonardo, Trigos Ángel, Couttolenc Alan, Padrón José M., Shnyreva Alla V., Mendoza Guillermo
Журнал: Food Science and Biotechnology
Том: 30
Номер: 5
Год издания: 2021
Издательство: Korean Society of Food Science and Technology
Местоположение издательства: Korea, Republic of
Первая страница: 711
Последняя страница: 721
DOI: 10.1007/s10068-021-00903-1
Аннотация: In this bioprospecting study the biological activities of extracts of the in vitro culture of Ganoderma Mexican strains were evaluated. The extracts were tested by the Sulforhodamine B staining method for antiproliferative activity and the plate microdilution method for antibacterial activity. Extracts that proved bioactive in these two activities, the antioxidant activity (Galvinoxyl, ABTS, and DPPH) and total phenolic contents (Folin-Ciocalteu) were additionally determined, as well as acute toxicity (Artemia franciscana). In the antiproliferative activity Ganoderma curtisii strain (GH-16-015) obtained a remarkable value of GI50 ≤ 50 µg/mL against tumor lines: A549, HBL-100, HeLa, and T-47D. G. curtisii strains (GH-16-012 and GH-16-015) showed MIC values = 500 µg/mL against Staphylococcus aureus. G. curtisii strain (GH-16-012) almost reduced by 50% the radical Galvinoxyl. Finally, G. curtisii strain (GH-16-023) presented the lowest level of toxicity with a LC50 of 490.881 µg/mL against A. franciscana. These results support the potential medicinal effects of Mexican strains of G. curtisii.
Добавил в систему: Шнырева Алла Викторовна

	ИСТИНА	Войти в систему Регистрация
	ИСТИНА ИНХС РАН
	Главная Поиск Статистика О проекте Помощь

ИСТИНА

ИСТИНА ИНХС РАН

Antiproliferative and antibacterial activity of extracts of Ganoderma strains grown in vitroстатья

Прикрепленные файлы