pH-Sensitive liposomes with embedded ampholytic derivatives of cholan-24-oic acidстатья
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Дата последнего поиска статьи во внешних источниках: 26 января 2022 г.
Аннотация:Stimulus-sensitive liposomes have been prepared from zwitterionic dioleoylphosphocholine and ampholytic molecular switches with carboxylic anionic groups and the triazole or isobutylamino cationic ones attached to the opposite ends of the steroid core. When altering the pH of outer solution from slightly alkaline to slightly acidic, the switches changed their orientation in the liposomal membrane, which induced temporal defects formation and the release of a drug model load. The low-toxic pH-sensitiveisobutylamino derivative–dioleoylphosphocholine liposomes demonstrated fast cargo release.