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Copper coordination compounds with (5Z,5Z')-2,2'-(alkane-α,ω-diyldiselenyl)-bis-5-(2-pyridylmethylene)-3,5-dihydro-4H-imidazol-4-ones. Comparison with sulfur analoguesстатья
Информация о цитировании статьи получена из
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Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 11 мая 2022 г.
- Авторы: Finko Alexander, Sokolov A.I., Tafeenko Viktor A., Guk Dmitry, Moiseeva Anna, Skvortsov Dmitry, Stomakhin Andrei, Beloglazkin Andrei, Borisov Roman, Pergushov Vladimir, Melnikov Mikhail, Zyk Nikolai, Majouga Alexander, Beloglazkina Elena
- Журнал: RSC advances
- Номер: 12
- Год издания: 2022
- Издательство: Royal Society of Chemistry
- Местоположение издательства: United Kingdom
- Первая страница: 7133
- Последняя страница: 7148
- DOI: 10.1039/D1RA08995A
- Аннотация: A series of new organic ligands (5Z,5Z')-2,2'-(alkane-α,ω-diyldiselenyl)-bis-5-(2-pyridylmethylene)-3,5-dihydro-4H-imidazol-4-ones (L) consisting of two 5-(2-pyridylmethylene)-3,5-dihydro-4H-imidazol-4-ones units linked with polymethylene chains of various lengths (n = 2–10, where n is the number of CH2 units) have been synthesized. The reactions of these ligands with CuCl2 .2H2O and CuClO4 .6H2O gave Cu+2 or Cu+1 containing mono- and binuclear complexes with Cu2LClх (x = 2-4) or CuL(ClO4)y (y = 1, 2) composition. It was shown that the agents reducing of Cu+2 to Cu+1 in the course of complexes formation can be both a ligand and an organic solvent in which the reaction is carried out. This fundamentally distinguishes the selenium-containing ligands L from their previously described sulfur analogs, which by themselves are not capable to reduce Cu+2 during complexation under the same conditions. A higher cytotoxicity and reasonable selectivity to cancer cell lines for synthesized complexes of selenium-containing ligands was shown; unlike sulfur analogs, ligands L themselves demonstrate a high cytotoxicity, comparable in some cases to the toxicity of copper-containing complexes.
- Добавил в систему: Белоглазкина Елена Кимовна