Interaction of copolymers of dimethylsiloxane and ethylene oxide with model membranes and cancerous cellsстатья
Информация о цитировании статьи получена из
Web of Science ,
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Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 7 декабря 2013 г.
Авторы:
Pavlov D.N. ,
Dorodnykh T.Y. ,
Zaborova O.V. ,
Melik-Nubarov N.S.
Журнал:
Polymer Science, Series A
Том:
51
Номер:
3
Год издания:
2009
Издательство:
Pleiades Publishing, Ltd
Местоположение издательства:
Road Town, United Kingdom
Первая страница:
295
Последняя страница:
301
DOI:
10.1134/S0965545X09030080
Аннотация:
Interaction of amphiphilic copolymers and ethylene oxide and dimethylsiloxane with biological membranes is studied. Copolymers are shown to increase the permeability of model membranes. Has been shown that their effect on the permeability of liposomal membranes with respect to dye carboxyfluoresceine correlates with their toxicity. At low nontoxic concentrations, Pluronic L61, a diblock copolymer of dimeth-ylsiloxane and ethylene oxide similar to triblock copolymer of ethylene and propylene oxides, is able to reduce the concentration of chemotherapeutic drug doxorubicin by a factor of 30, which is toxic to cancerous cells stable to remedy drugs. © 2009 Pleiades Publishing, Ltd.
Добавил в систему:
Мелик-Нубаров Николай Сергеевич