A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larva

Shatilovich, A.; Gade, V.R.; Pippel, M.; Hoffmeyer, T.T.; Tchesunov, A.V.; Stevens, L.; Winkler, S.; Hughes, G.M.; Traikov, S.; Hiller, M.; Rivkina, E.; Schiffer, P.H.; Myers, E.W.; Kurzchalia, T.V.

Авторы: Shatilovich A., Gade V.R., Pippel M., Hoffmeyer T.T., Tchesunov A.V., Stevens L., Winkler S., Hughes G.M., Traikov S., Hiller M., Rivkina E., Schiffer P.H., Myers E.W., Kurzchalia T.V.
Журнал: PLoS Genetics
Том: 19
Номер: 7
Год издания: 2023
Издательство: Public Library of Science
Местоположение издательства: United States
DOI: 10.1371/journal.pgen.1010798
Аннотация: Some organisms in nature have developed the ability to enter a state of suspended metabolismcalled cryptobiosis when environmental conditions are unfavorable. This state-transitionrequires execution of a combination of genetic and biochemical pathways that enablethe organism to survive for prolonged periods. Recently, nematode individuals have beenreanimated from Siberian permafrost after remaining in cryptobiosis. Preliminary analysisindicates that these nematodes belong to the genera Panagrolaimus and Plectus. Here, wepresent precise radiocarbon dating indicating that the Panagrolaimus individuals haveremained in cryptobiosis since the late Pleistocene (~46,000 years). Phylogenetic inferencebased on our genome assembly and a detailed morphological analysis demonstrate thatthey belong to an undescribed species, which we named Panagrolaimus kolymaensis.Comparative genome analysis revealed that the molecular toolkit for cryptobiosis in P. kolymaensisand in C. elegans is partly orthologous. We show that biochemical mechanismsemployed by these two species to survive desiccation and freezing under laboratory conditionsare similar. Our experimental evidence also reveals that C. elegans dauer larvae canremain viable for longer periods in suspended animation than previously reported. Altogether,our findings demonstrate that nematodes evolved mechanisms potentially allowingthem to suspend life over geological time scales.
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A novel nematode species from the Siberian permafrost shares adaptive mechanisms for cryptobiotic survival with C. elegans dauer larvaстатья

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