Cu (II) and Ni (II) complexes of 1-(N-phenylthiocarbamoyl)-pyrazolines: Synthesis, electrochemistry and cytotoxic properties

Vorozhtsov, N.I.; Korablina, D.D.; Kalenikova, E.I.; Sviridova, L.A.; Petkova, A.I.; Moiseeva, A.A.; Tafeenko, V.A.; Ataeva, A.N.; Makhmudova, B.V.; Markova, A.A.; Shtil, A.A.; Zyk, N.V.; Beloglazkina, E.K.

Информация о цитировании статьи получена из Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 июля 2024 г.

Авторы: Vorozhtsov Nikolai I., Korablina Diana D., Kalenikova Elena I., Sviridova Lyudmila A., Petkova Aneliia I., Moiseeva Anna A., Tafeenko Viktor A., Ataeva Aida N., Makhmudova Bakhu V., Markova Alina A., Shtil Alexander A., Zyk Nikolai V., Beloglazkina Elena K.
Журнал: Results in Chemistry
Том: 9
Год издания: 2024
Издательство: Elsevier B.V.
Местоположение издательства: Netherlands
Номер статьи: 101632
DOI: 10.1016/j.rechem.2024.101632
Аннотация: Two series of novel Cu (II) (4a–e) and Ni (II) (5a–e) complexes bearing 1-(N-phenylthiocarbamoyl)-pyrazoline ligands (3a–e) were synthesized and characterized. The structures of Ni (II) complexes 5a, c were confirmed by X-ray crystallography; both complexes have a distorted octahedral coordination environment of the Ni (II); metal atoms are coordinated by pyridyl and pyrazoline nitrogen atoms and thiocarbonyl sulfur of two ligand moiety, with two chloride anions in the outer sphere. The Cu (II) complex 4a derived from ligand 3a demonstrate a non-typical electrochemical behavior indicating Cu (I) complex formation which can be explained either by pyrazoline ligand ring opening in DMF solution or by a non-innocent nature of 3a. All of the synthesized complexes were cytotoxic against HCT116 and К562 cell lines; the most cytotoxic ligand was 3d, which is structurally related to combretastatin A4.
Добавил в систему: Белоглазкина Елена Кимовна

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Cu (II) and Ni (II) complexes of 1-(N-phenylthiocarbamoyl)-pyrazolines: Synthesis, electrochemistry and cytotoxic propertiesстатья

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