The establishment of the 3D genome structure during zygotic genome activation

Авторы: Sivkina Anastasiia L., Iarovaia Olga V., Razin Sergey V., Ulianov Sergey V.
Журнал: Annals of the New York Academy of Sciences
Год издания: 2025
Издательство: New York Academy of Sciences
Местоположение издательства: United States
DOI: 10.1111/nyas.15304
Аннотация: During zygotic genome activation (ZGA) and early development, hierarchical levels of chromatin structure undergo remarkable perturbations: changes in the nuclear-to- cytoplasmic ratio of various components; changes in chromatin accessibility; histone exchange; and the formation of 3D structures such as loops, topologically associated domains, and compartments. Here, we review the peculiarities, variability, and emer- gence of the chromatin structural features during ZGA in different organisms. Focusing on newly found structures called fountains, we describe the prerequisites for cohesin loading on DNA and possible mechanisms of genome organization in early devel- opment. Fountains resulting from asymmetric bidirectional cohesin extrusion spread from cohesin-loading points in a CTCF-independent manner. We discuss that foun- tains may not possess specific functions, unlike conventional chromatin structures, and could be found in other biological processes where cohesin loading occurs
Добавил в систему: Разин Сергей Владимирович

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