Effects of diadenosine polyphosphates on bioelectrical and contractile activity of the rat heartстатьяТезисы
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Дата последнего поиска статьи во внешних источниках: 27 февраля 2017 г.
Аннотация:Aim: Diadenosine polyphosphates (Ap(n)A) are naturally occurring molecules, but their
physiological role has not been established. In several studies Ap(n)A were demonstrated to
participate in smooth muscle tone regulation,however, effects of Ap(n)A in heart were not
investigated. The aim of present study was to elucidate effects of diadenosine tetra- and
diadenosine pentaphosphate (Ap4A, Ap5A) on bioelectrical and contractile activity of rat
myocardium and to compare Ap(n)A-induced effects with effects of adenosine (Ado) and ATP.
Methods: Standard microelectrode technique was used to investigate influence Ap4A or Ap5A (1-10
µM) on action potentials duration (APD) in isolated, Tyrode perfused, electrically paced (3.3 Hz)
multicellular preparations of left (LA) and right atria (RA), or ventricular wall (RV) of rat heart.
Myocardium preparations were dissected from male Wistar (200-250 g) rats. Left ventricle (LV)
contractility under Ap4A or Ap5A action was estimated with use of Langendorf perfused isolated
rat hearts. All experiments were approved by local bioethical committee.
Results: Administration of Ap4A, Ap5A (10 µM) caused significant (p(T)<0.05, n>6 for all groups)
decreasing of APD in rat LA (to 77±5% and 89±2 %), RA (78±4% and 71±5%, n=6) and RV (65±3%
and 46±4%, n=6). APD decreasing, induced by Ap4A and Ap5A were similar with such of 10 µM
Ado or ATP (p(U)>0.1). Both Ap4A, Ap5A induced significant dose-dependent multiphase changes of
rat myocardium contractility. Conclusions: Ap4A and Ap5A have profound effect on the bioelectrical activity of atrial and ventricular rat myocardium, contractile activity of left
ventricle. Diadenosine polyphosphates action in heart may be mediated by the similar mechanisms
with classical purinergic agonists - Ado and ATP.