Variable and low-toxic polyampholytes: complexation with biological membranes

Yaroslavov, A.A.; Sitnikova, T.A.; Rakhnyanskaya, A.A.; Yaroslavova, E.G.; Sybachin, A.V.; Melik-Nubarov, N.S.; Khomutov, G.B.

Информация о цитировании статьи получена из Web of Science, Scopus
Статья опубликована в журнале из списка Web of Science и/или Scopus
Дата последнего поиска статьи во внешних источниках: 17 октября 2017 г.

Авторы: Yaroslavov A.A., Sitnikova T.A., Rakhnyanskaya A.A., Yaroslavova E.G., Sybachin A.V., Melik-Nubarov N.S., Khomutov G.B.
Журнал: Colloid and Polymer Science
Том: 295
Номер: 8
Год издания: 2017
Издательство: Springer Verlag
Местоположение издательства: Germany
Первая страница: 1405
Последняя страница: 1417
DOI: 10.1007/s00396-017-4054-4
Аннотация: In this paper, we describe three series of polyampholytes synthesized via quaternization of poly(4-vinylpyridin) by ω-bromocarboxylic acids and alkyl bromides: (1) with cationic and anionic groups in each unit (polybetaines), (2) with betaine and cationic groups, and (3) with betaine and pendant alkyl groups. The polymers were complexed with anionic mixed lipid membranes, liposomes, and Langmuir monolayers. By varying a length of –(CH2)n– spacer in the betaine group, different behaviors of polybetaines in a suspension of anionic liposomes can be realized: from no interaction to complexation followed by significant structural reorganization in the liposomal membrane. Cytotoxicities of polyampholytes are one to two orders of magnitude less than the cytotoxicity of a pure polycationic polymer with the same degree of polymerization. These results are of importance in designing polyelectrolytes with a higher affinity to the biolodical (cell) membrane and minimum cytotoxicity and demonstrate the potential of polyampholytes in developing biocompatible polymeric structures.
Добавил в систему: Сыбачин Андрей Владимирович

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Variable and low-toxic polyampholytes: complexation with biological membranesстатья

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